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a Departments of
Laboratory Medicine, b and Obstetrics
and Gynaecology, c Osaka University Medical School, Osaka, Japan
Correspondence to: Dr N Amino, Department of Laboratory Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, Japan.
Accepted for publication 18 June 1998
OBJECTIVE
To
investigate the prediction of the postpartum onset of rheumatoid
arthritis (RA).
METHODSTwo thousand
five hundred and forty seven healthy pregnant subjects were examined
prospectively and the relation between serum rheumatoid factors (RF)
and postpartum onset of RA was observed. Rheumatoid factors were
measured in early pregnancy by the antihuman IgG latex agglutination
test (Latex test) and antirabbit IgG haemagglutination test (RAHA test).
RESULTSLatex test and
RAHA test were positive in 26 (1.0%) and 64 (2.5%) pregnant subjects,
respectively. Four hundred and ten subjects of 2547 pregnant women
could be followed up for one year after delivery. None of 401 subjects
without RF, or with only one RF on either Latex test or RAHA test,
developed RA after delivery. Two (22.2%) of nine subjects with both
RFs developed RA at one and three months postpartum, respectively.
Transient arthralgia was found within 12 months postpartum in three of
nine (33.3%) subjects with both RFs and this prevalence was
significantly higher than that in RF negative subjects (8.1%).
CONCLUSIONPostpartum
onset of RA was found in at least 2 of 2547 healthy subjects (0.08%)
and onset was predicted by positive test for rheumatoid factors.
This article has been cited by other articles:
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  M. Gayed and C. Gordon Pregnancy and rheumatic diseases Rheumatology, November 1, 2007; 46(11): 1634 - 1640. [Abstract] [Full Text] [PDF]
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