| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a ARC
Epidemiology Unit, University of Manchester, Stopford Building, Oxford
Road, Manchester M13 9PT, b Norfolk Arthritis Register, St Michaels
Hospital, Aylsham, Norfolk
Correspondence to: Professor Silman
Accepted for publication 12 October 1999
OBJECTIVES
To
determine whether there is any evidence that there are spatial clusters
of rheumatoid arthritis in particular, and inflammatory arthritis in general.
METHODSSetting was a
population based incidence register of inflammatory arthritis: the
Norfolk Arthritis Register (NOAR). All cases identified between
1990-1995 were mapped to place of residence. Statistical evidence of
clustering was determined by calculating Poisson probabilities in
putative areas.
RESULTSThree clusters
were identified including one small area (population 85) where five
unrelated cases developed during this time period. There was no obvious
greater disease homogeneity within clusters and no common environmental
factors were identified.
CONCLUSIONRare
clusters of inflammatory polyarthritis do occur. Their significance and
cause remain to be elucidated.
This article has been cited by other articles:
|
|
 |
|
  S M Carty, N Snowden, and A J Silman Should infection still be considered as the most likely triggering factor for rheumatoid arthritis? Ann Rheum Dis, November 1, 2004; 63(suppl_2): ii46 - ii49. [Full Text] [PDF]
|
|
|
|
|
|
L B A van de Putte, R Rau, F C Breedveld, J R Kalden, M G Malaise, P L C M van Riel, M Schattenkirchner, P Emery, G R Burmester, H Zeidler, et al. Efficacy and safety of the fully human anti-tumour necrosis factor {alpha} monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study Ann Rheum Dis, December 1, 2003; 62(12): 1168 - 1177. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
