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a Turku Immunology
Centre and Departments of Virology, Medical Microbiology and Medicine,
University of Turku and Turku University Central Hospital, Turku,
Finland, b Department of Rheumatology, Satalinna Hospital,
Satalinna, Finland, c Division
of Rheumatology, Department of Medicine, Oulu University Hospital,
Oulu, Finland, d Department
of Medicine, Tampere University Hospital, Tampere, Finland, e Department of Medicine,
Jyväskylä Central Hospital, Jyväskylä, Finland
Correspondence to: Dr Laivoranta-Nyman, Medicity Research Laboratory, Turku University, Tykistökatu 6A, FIN-20520 Turku, Finland
Accepted for publication 10 December 1999
OBJECTIVE
To search
for possible immunogenetic differencies between the patients with
familial and non-familial rheumatoid arthritis (RA).
METHODSThe study
compared 129 familial RA patients with 217 non-familial patients for
the frequencies of HLA-DR antigens including DR4 subtypes,
DR4-DQB1*0301 and DR4-DQB1*0302 haplotypes and HLA-B27 antigen as well
as the age of disease onset and existence of rheumatoid factor or joint erosions.
RESULTSTwo major
differences between familial and non-familial groups were found:
firstly, familial RA patients had increased frequency of HLA-DR4 as
compared with the non-familial RA group (68.2 v 54.8%; p = 0.019). Secondly, the mean age at onset of RA was
significantly lower in the familial than in the sporadic RA patients
(42.0 v 46.5 years; p = 0.0020) and the
difference still remained when the DR4 positive and negative subgroups
were compared separately.
CONCLUSIONThese
results confirm the more prominent association with HLA-DR4 in familial
than in the non-familial cases and suggest that accumulation of HLA
risk genes may, at least partly, explain the familial occurrence of the
disease. Other susceptibility genes may also be concentrated in
multiplex case families as suggested by an earlier age at the onset of
RA in both HLA-DR4 positive and negative familial patients.
This article has been cited by other articles:
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  S Laivoranta-Nyman, T Mottonen, R Hermann, J Tuokko, R Luukkainen, M Hakala, P Hannonen, M Korpela, U Yli-Kerttula, A Toivanen, et al. HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis Ann Rheum Dis, November 1, 2004; 63(11): 1406 - 1412. [Abstract] [Full Text] [PDF]
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 A. Gul, F. A. Uyar, M. Inanc, L. Ocal, I. Tugal-Tutkun, O. Aral, M. Konice, and G. Saruhan-Direskeneli Lack of association of HLA-B*51 with a severe disease course in Behcet's disease Rheumatology, June 1, 2001; 40(6): 668 - 672. [Abstract] [Full Text] [PDF]
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S Laivoranta-Nyman, R Luukkainen, M Hakala, P Hannonen, T Mottonen, U Yli-Kerttula, J Ilonen, and A Toivanen Differences between female and male patients with familial rheumatoid arthritis Ann Rheum Dis, April 1, 2001; 60(4): 413 - 415. [Abstract] [Full Text] [PDF]
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