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a Jan van Breemen
Institute, Amsterdam, the Netherlands, b Department of Rheumatology, University Hospital
Vrije Universiteit, Amsterdam, c Department of Pathology, University Hospital
Vrije Universiteit, Amsterdam, d Department
of Epidemiology and Biostatistics, University Hospital Vrije
Universiteit, Amsterdam
Correspondence to: Dr van der Horst-Bruinsma, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, the Netherlands
Accepted for publication 16 December 1999
OBJECTIVE
To compare
the prevalence of Chlamydia trachomatis
infections in ankylosing spondylitis (AS) patients with controls, using DNA amplification assays in urine specimens.
METHODSThe prevalence
of C trachomatis infections was assessed in
32 male AS patients and 120 age and sex matched controls. Urine specimens were tested by ligase chain reaction and polymerase chain
reaction. In addition, blood samples of AS patients were tested on
serum antibodies to C trachomatis (IgA and
IgG) by a specific peptide based solid phase enzyme immunoassay. A
questionnaire was used to assess the differences in sexual behaviour
and ethnic origin between the two groups. AS patients were also asked
about disease characteristics.
RESULTSNo significant
differences were found between cases and controls in the prevalence of
C trachomatis infections. No associations were found between C trachomatis antibodies
and disease characteristics, except for acute anterior uveitis (AAU).
Four of eight (50%) AS men positive for IgG had a history of AAU in
comparison with three of 24 (12.5%) IgG negative men (OR = 7.0; 95%
confidence intervals: 1.1, 44.1).
CONCLUSIONThe
prevalence of Chlamydia trachomatis
infections, as detected by commercially available DNA amplification
assays in urine specimens, in AS patients is not higher compared with
male controls of the same age. However, there seems to be an
association between specific antibodies to C
trachomatis and AAU.
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  M van der Paardt, J B A Crusius, M H M T de Koning, S A Morre, R J van de Stadt, B A C Dijkmans, A S Pena, and I E van der Horst-Bruinsma No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis Ann Rheum Dis, February 1, 2005; 64(2): 235 - 238. [Abstract] [Full Text] [PDF]
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M Huhtinen, K Laasila, K Granfors, M Puolakkainen, I Seppala, L Laasonen, H Repo, A Karma, and M Leirisalo-Repo Infectious background of patients with a history of acute anterior uveitis Ann Rheum Dis, November 1, 2002; 61(11): 1012 - 1016. [Abstract] [Full Text] [PDF]
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