| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Orton, Invalid
Foundation, Helsinki, Finland, b National Public Health Institute, Helsinki,
Finland, c United Laboratories Ltd, Helsinki, Finland, d Division
of Rheumatology, Department of Medicine, Helsinki University Central
Hospital, Helsinki, Finland, e Department of Microbiology, Boden Hospital,
Boden, Sweden
Correspondence to: Dr L Paimela, Orton, Invalid Foundation, Tenholantie 10, FIN-00280 Helsinki, Finland leena.paimela{at}invalidisaatio.fi
Accepted for publication 7 June 2000
OBJECTIVE
To evaluate
the clinical significance of antifilaggrin antibodies (AFA) measured by
an enzyme linked immunosorbent assay (ELISA) in serial specimens from
patients with recent onset rheumatoid arthritis (RA).
METHODSFilaggrin was
purified from human skin and used as an antigen in ELISA. The AFA test
was applied to five serial specimens from 78 patients with recent onset
RA followed up for three years. Rheumatoid factor (RF) had been
measured earlier from the same samples by quantitative immunoturbidimetry.
RESULTSThe mean AFA
level was highest at entry (54% positive), followed by a statistically
significant decline at six months and a slight increase at three years.
AFA were persistently positive in 23 patients and persistently negative
in 28 patients. Eleven of the latter patients were persistently
negative for RF. At study entry AFA levels correlated to some degree
with RF levels. In general, raised AFA levels at entry were associated
with an active and treatment resistant disease, but they did not
predict radiological progression.
CONCLUSIONSThe test
for AFA has potential for an additional immunological test for RA.
This article has been cited by other articles:
|
|
 |
|
  S. Chapuy-Regaud, M. Sebbag, D. Baeten, C. Clavel, C. Foulquier, F. De Keyser, and G. Serre Fibrin Deimination in Synovial Tissue Is Not Specific for Rheumatoid Arthritis but Commonly Occurs during Synovitides J. Immunol., April 15, 2005; 174(8): 5057 - 5064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Caponi, E Petit-Teixeira, M Sebbag, F Bongiorni, S Moscato, F Pratesi, C Pierlot, J Osorio, S Chapuy-Regaud, M Guerrin, et al. A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population Ann Rheum Dis, April 1, 2005; 64(4): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J-E Gottenberg, S Mignot, P Nicaise-Rolland, J Cohen-Solal, F Aucouturier, J Goetz, C Labarre, O Meyer, J Sibilia, and X Mariette Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome Ann Rheum Dis, January 1, 2005; 64(1): 114 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I Vallbracht, J Rieber, M Oppermann, F Forger, U Siebert, and K Helmke Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis Ann Rheum Dis, September 1, 2004; 63(9): 1079 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Meyer, C Labarre, M Dougados, P. Goupille, A Cantagrel, A Dubois, P Nicaise-Roland, J Sibilia, and B Combe Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage Ann Rheum Dis, February 1, 2003; 62(2): 120 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Genevay, G Hayem, P Verpillat, and O Meyer An eight year prospective study of outcome prediction by antiperinuclear factor and antikeratin antibodies at onset of rheumatoid arthritis Ann Rheum Dis, August 1, 2002; 61(8): 734 - 736. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
